The space radiation: nature, biological effects and shielding

1Muradian, Kh.K
1State Institution "D.F.Chebotarov Institute of Gerontology of the National Academy of Medical Sciences of Ukraine", Kyiv, Ukraine
Kosm. nauka tehnol. 2002, 8 ;(1):107-113
Section: Space Life Sciences
Publication Language: Russian
Abstract: 
The latest findings in origin, biological effects and shielding of the space ionizing radiation (SIR) are reviewed. It is stressed that after the impending implementation of artificial gravity, SIR could become the most serious concern for deep space travelers. SIR is more effective in induction of the genome- and cell-associated damages, compared with the conventional radioactive sources. The shielding of SIR is augmented due to the secondary spallation S -radiation and possible cooperation with weightlessness and other negative impacts of a space flight. The panspermia concept postulating the existence of living organisms, e. g. bacterial spores, in space and their natural interplanetary transportation is discussed.
Keywords: biological effects, ionizing radiation, shielding
References: 
1. Bondarenko V. A., Mitrikas V. G., Tsetlin V. V. Radiation environment of orbital complex "Mir" during minimum of the 22-nd solar cycle (1994-1996). Aviakosm. Ekolog. Med., 34 (1), 21—24 (2000) [in Russian].
2. Guliaeva T. L. Lethal Manifestations of Meteorological and Cosmic Factors. Biofizika, 43 (5), 833—839 (1998) [in Russian].
3. Badhwar G. D. Radiation measurements in low Earth orbit: U. S. and Russian results. Health Phys., 79, 507— 514 (2000).
4. Bagshaw M., Irvine D., Davies D. M. Exposure to cosmic radiation of British Airways flying crew on ultralong haulroutes. Occup. Environ. Med., 53, 495—498 (1996).
5. Brackley M. E., Curry J., Glickman B. W. A note on the relevance of human population genetic variation and molecular epidemiology to assessing radiation health risk for space travellers. Mutat. Res., 430, 293—298 (1999).
6. Brooks A., Bao S., Rithidech K., et al. Relative effectiveness of HZE iron-56 particles for the induction of cytogenetic damage in vivo. Radiat. Res., 155, 353—359 (2001).
7. Chang P. Y., Kanazawa N., Lutze-Mann L., Winegar R. HZE particle radiation induces tissue-specific and p53-dependent mutagenesis in transgenic animals. Phys. Medica, 17 (Suppl.), 1—3 (2000).
8. Clark B. C. Planetary interchange of bioactive material: probability factors and implications. Orig. Life Evol. Biosph., 31, 185—197 (2001).
9. Cucinotta F. A., Wilson J. W. Initiation-promotion model of tumor prevalence in mice from space radiation exposures. Radiat. and Environ. Biophys., 34, 145—149 (1995).
10. Davies P. C. The transfer of viable microorganisms between planets. Ciba Found Symp., 202, 304—311 (1996).
11. Dousset N., Moatti J. P., Moatti N., et al. Influence of the environment in space on the biochemical characteristics of human low density lipoproteins. Free Radic. Res., 24, 69—74 (1996).
12. Edwards A. A. The use of chromosomal aberrations in human lymphocytes for biological dosimetry. Radiat. Res., 48 (5 Suppl.), 39—44 (1997).
13. George K., Wu H., Willingham V., et al. High- and low-LET induced chromosome damage in human lymphocytes: a time-course of aberrations in metaphase and interphase. Int. J. Radiat. Biol., 77, 175—183 (2001).
14. Hamm P. B., Billica R. D., Johnson G. S., et al. Risk of cancer mortality among the Longitudinal Study of Astronaut Health (LSAH) participants. Aviat. Space Environ Med., 69, 142—144 (1998).
15. Hamm P. B., Nicogossian A. E., Pool S. L., et al. Design and current status of the longitudinal study of astronaut health. Aviat. Space Environ. Med., 71, 564—70 (2000).
16. Hartman P. S., Hlavacek A., Wilde H., et al. A comparison of mutations induced by accelerated iron particles versus those induced by low earth orbit space radiation in the FEM-3 gene of Caenorhabditis elegans. Mutat. Res., 474, 47—55 (2001).
17. Hollander J., Gore M., Fiebig R., et al. Spaceflight downregu-lates antioxidant defense system in rat liver. Free Radic. Biol. Med., 24, 385—90 (1998).
18. Horneck G. Impact of microgravity on radiobiological processes and efficiency of DNA repair. Mutat. Res., 430, 221—228 (1999).
19. Ianzini F., Cherubini R., Mackey M. A. Mitotic catastrophe induced by exposure of V79 Chinese hamster cells to low-energy protons. Int. J. Radiat. Biol., 75, 717— 723 (1999).
20. James J. T. Carcinogens in spacecraft air. Radiat. Res., 148 (5 Suppl.), 11 — 16 (1997).
21. Kawata T., Durante M., Furusawa Y., et al. Dose-response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions. Int. J. Radiat. Biol., 77, 165—174 (2001).
22. Lackner J. R., DiZio P. Artificial gravity as a countermeasure in long-duration space flight. J. Neurosci. Res., 62, 169—176 (2000).
23. Levine D. D., Greenleaf J. E. Immunosuppression during spaceflight deconditioning. Aviat. Space Environ. Med., 69, 172—177 (1998).
24. Nicholson W. L., Munakata N., Horneck G., et al. Resistance of Bacillus endospores to extreme terrestrial and extraterrestrial environment. Microbiol. Mol. Biol. Reviews, 64, 548—572 (2001).
25. Nicogossian A. E., Pober D. F., Roy S. A. Evolution of telemedicine in the space program and earth applications. Telemed. J. E. Health, 7, 1 — 15 (2001).
25. Pross H. D., Casares A., Kiefer J. Induction and repair of DNA double-strand breaks under irradiation and microgravity. Radiat. Res., 153, 521—525 (2000).
27. Setlow R. B. The U. S. National Research Council's views of the radiation hazards in space. Mutat. Res., 430, 169—175 (1999).
28. Simonsen L. C, Wilson J. W., Kim M. H., Cucinotta F. A. Radiation exposure for human Mars exploration. Health. Phys., 79, 515—525 (2000).
29. Sinclair W. K. Dose limits for astronauts. Health Phys., 79, 585—590 (2000).
30. Stoupel E., Israelevich P., Gabbay U., et al. Correlation of two levels of space proton flux with monthly distribution of deaths from cardiovascular disease and suicide. J. Basic Clin. Physiol. Pharmacol., 11, 63—71 (2000).
31. Sullivan R. The hazards of reproduction in space. Acta Obstat. Gynecol. Scand., 75, 372—377 (1996).
32. Takahashi A., Ohnishi K., Takahashi S., et al. The effects of microgravity on ligase activity in the repair of DNA double-strand breaks. Int. J. Radiat. Biol., 76, 783—788 (2000).
33. Thomson I. EVA dosimetry in manned spacecraft. Mutation Res., 430, 203—209 (1999).
34. Timchenko A. N., Muradian Kh. K. Optimal hypogravity: a panacea in manned space flights? 17th Congress of the International Association of Gerontology, Vancouver, Canada, July 1—6, 2001, Abstracts. Gerontology, 47 (Suppl. 1), 102 (2001).
35. Todd P., Pecaut M. J., Fleshner M. Combined effects of space flight factors and radiation on humans. Mutat. Res., 430, 211—219 (1999).
36. Yang T. C., George K., Craise L. M., Durante M. Initiation of oncogenic transformation in mammary epithelial cells by charged particles. Radiat. Oncol. Investig., 5, 134—138 (1997).
37. Yang T. C., George K., Johnson A. S., et al. Biodosimetry results from space flight Mir-18. Radiat. Res., 148 (5 Suppl.), 17—23 (1997).
38. Yasuda H., Badhwar G. D., Komiyama T., Fujitaka K. Effective dose equivalent on the ninth Shuttle—Mir mission (STS-91). Radiat. Res., 154, 705—713 (2000).

39. Young L. R. Artificial gravity considerations for a Mars exploration mission. Annals N. Y. Acad. Sci., 871, 367—378 (1999).