Dosed hypoxia correction effect on the weightlessness osteopenia

1Litovka, IG
1Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Kosm. nauka tehnol. 2002, 8 ;(4):081-085
Section: Space Life Sciences
Publication Language: Russian
Abstract: 
We investigated the influence of a dosed condition regime of breathing the artificial gaz mixture with a lower P0   at the normal

atmospheric pressure on the biochemical indices of bones after axial unloading of rear extremities of rats of different age. The gaz mixture with a lower oxygen content supplied in the faltering regime activizes the rat bone tissue remodeling and hinders the destructive processes to a greater extent in young animals compared to adult ones.

Keywords: biochemical indices, bones, dosed hypoxia
References: 
1. Avrunin A. S., Kornilov N. V., Sukhanov A. V., Emelianov V. G. Formation of osteoporotic changes in the structure of the bone, 68 p. (Olga, SPb., 1998) [in Russian].
2. Astakhova V. S., Berezovskii V. Ya., Panchenko L. M., Khasabova I. A. The stromal cells of human bone-marrow cloning by of low partial oxygen pressure. Fiziologichnyj  Zhurnal, 47 (1), pt. 2, 40—44 (2001) [in Ukrainian].
3. Berezovsky V. A., Deynega V. G. Physiological mechanisms of sanogenic effects of mountain climate, 222 p. (Nauk. dumka, Kiev, 1988) [in Russian].
4. Berezovsky V. A., Levashov M. I. Physiological prerequisites and mechanisms of the normalizing effect of normobaric hypoxia and orotherapy. Fiziol. Zh., 38 (5), 3—12 (1992) [in Russian].
5. Berezovsky V. A., Litovka I. G., Chaka E. G. The effect of measured hypoxia on the development of situational osteopenia. Fiziologichnyj Zhurnal, 46 (1), 10—16 (2000) [in Ukrainian].
6. Berezovsky V. A., Litovka I. G., Chaka E. G., Lakhin P. V. Influence of reduced РО2 on modulation of osteodystrophy in rats
under various statokinetic conditions. Fiziologichnyj  Zhurnal, 47 (1), pt. 2, 50—54 (2001) [in Ukrainian].
7. Berezovsky V. A., Litovka I. G., Chaka E. G., et al. Biophysical stimulation of  osteogenesis. Problems of Osteology, 2 (2), 12—15 (1999) [in Russian].
8. Berezovskii V. A., Litovka I. G., Chaka H. G., et al. Effect of the intermittent hypoxia on the bone tissue state after microgravitation modeling. Kosm. nauka tehnol., 6 (2-3), 77—84 (2000) [in Russian].
9. Volkov N. I. The Modern Methods of Hypoxic Sports Training. In: Tretii mezhdunarodnyi kongress po teorii deyatel’nosti i sotsial’noi praktike [Proc. Third Int. Congress on Theory of Activities and Social Practice], P. 27 (Fizkul'tura, obrazovanie, nauka, Moscow, 1995) [in Russian].
10. Volkov N. I., Brovko A. P., Fefilat’ev L. P., Bugaev S. A. Physiological Effects of Interval Hypoxia. In: Pervyi Rossiiskii kongress po patofiziologii. Patofiziologiya organov i sistem. Tipovye patofiziologicheskie protsessy (eksperimental’nye i klinicheskiye aspekty) [First Russian Congress on Pathophysiology. Pathophysiology of Organs and Systems. Typical Pathophysiological Processes (Experimental and Clinical Aspects)], P. 117 (RGMU, Moscow, 1996) [in Russian].
11. Volozhin A. I., Lemetskaya T. I. Changes in calcium and phosphorus metabolism in bones and teeth with oxygen starvation. Patol. fiziologija i jeksperim. med., 14 (5), 16—20 (1970) [in Russian].
12. Kaplansky A. S., Durnova G. N., Sakharova Z. F., Il’ina-Kakuyeva E. I. Histomorphometric analysis of the bones of rats on board the Kosmos 1667 biosatellite. Kosm. Biol. Aviakosm. Med., 21 (5), 5—31 (1987) [in Russian].
13. Karash Yu . M., Strelkov R. B., Chizhov A. Ya. Normobaric hypoxia in treatment, prevention and rehabilitation, 351 p. (Moscow, 1988) [in Russian].
14. Klyatskin S. A., Lifshits P. I. Analysis of Glycosaminoglycans in the Blood of Patients by the Orcinol Method. Lab. delo, No. 9, 51—53 (1989) [in Russian].
15. Kovalenko E. A., Turovsky N. N. Hypokinesia, 320 p. (Medicine, Moscow, 1980) [in Russian].
16. Kolchinskaya A. Z. Oxygen. Physical state. Working capacity, 208 p. (Nauk. dumka, Kiev, 1991) [in Russian].
17. Meerson F. Z., Tverdokhlib V. P., Boev V. M., Frolov V. A. Adaptation to periodic hypoxia in therapy and prophylaxis, 228 p. (Nauka, Moscow, 1989) [in Russian].
18. Oganov V. S. Hipokinesia - the factor of risk of osteoporosis. Osteoporoz i osteopatii, No. 1, 13—17 (1988) [in Russian].
19. Oganov V. S., Brik A. B., Shcherbina, O. I., et al. On the Influence of Weight  Bearing Deficit on the Collagen–Crystal Relationship in Rat Bone Tissue accord ing to EPR Data. In: Kosmicheskaya biologiya i aviakosmicheskaya meditsina [Space Biology and Aerospace Medicine: Proc. XII Conf.], 255—256 (Moscow, 2002) [in Russian].
20. Smetanin V. Ya. Impact of different regimes of the interval hypoxic training on cardiorespiratory and hematological functions. Fiziologija cheloveka, 26 (4), 73—82 (2000) [in Russian].
21. Strelkov R. B., Chizhov A. Ya. Intermittent Normobaric Hypoxia in Prevention, Treatment, and Rehabilitation, 400 p. (Ural'skii Rabochii, Yekaterinburg, 2001) [in Russian].
22. Morey-Holton E. R., Wronski T. I. Animal models for simulating weightlessness. Physiologist, 24 (6), 45— 48 (1981).
23. Nishimyra Y., Fukuoka H., Kiriyama M., Suzuki Y. Bone turnover and calcium metabolism during 20 days bed rest in young healthy males and females. Acta physiol. Scand., 150 (616), suppl., 27—35 (1994).

24. Rambaut P. C., Johnson P. S. Prolonged weightlessness and calcium loss in man. Acta astronaut., 6 (9), 1113—1122 (1979).