The effects of DL-threots-benzyloxy-aspartate (DL-TBOA) on the synaptosomal glutamate release in media low in [Na+ ] under artificial gravity
|1Borisova, TA, 1Krisanova, NV, 2Himmelreich, NH |
1Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, Kyiv, Ukraine
2O.V. Palladin Institute of Biochemistry of the NAS of Ukraine, Kyiv, Ukraine
|Kosm. nauka tehnol. 2006, 12 ;(1):090-093|
|Publication Language: Russian|
L-glutamate release from cytosolic pool of brain synaptosomes after exposure of rats to artificial gravity loading was investigated using the inhibitor of glutamate transport as a tool. The nontransportable competitive inhibitor DL-threo-beta-benzylo-xyaspartate (DL-TBOA) was demonstrated to become more potent in Na and NMDG-supplemented media under centrifuge-induced hypergravity. We showed that DL-TBOA inhibited L-[14 C] glutamate release effectively in NMDG-supplemented media in comparison with Na+ -supplemented one.
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