The remodelling of bone tissue for low-and high-activity rats under a 45-day hypokinesy and the influence of measured oxygen deprivation

1Litovka, IG
1Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Kosm. nauka tehnol. 2003, 9 ;(1):092-095
Publication Language: Ukrainian
We investigate the influence of the normobaric gaz mixture with lowered P0  = 100... 110 mm Hg on the biochemical markers of the bone metabolism for rats with limited mobility. The gaz mixture with a lowered oxygen content supplied in the faltering regime activizes the rat bone tissue remodelling and hinders the development of destructive processes for young animals to a greater extent than for adult ones.
Keywords: bone tissue of rats, hypokinesia, oxygen deprivation
1. Avrunin A. S., Kornilov N. V., Sukhanov A. V., Emelianov V. G. Formation of osteoporotic changes in the structure of the bone, 68 p. (Olga, SPb., 1998) [in Russian].
2. Berezovsky V. A., Deynega V. G. Physiological mechanisms of sanogenic effects of mountain climate, 222 p. (Nauk. dumka, Kiev, 1988) [in Russian].
3. Berezovsky V. A., Levashov M. I. Physiological prerequisites and mechanisms of the normalizing effect of normobaric hypoxia and orotherapy. Fiziol. Zh., 38 (5), 3—12 (1992) [in Russian].
4. Grigor'ev A. I., Volozhin A. I., Stupakov G. P. Mineral metabolism in humans under conditions of altered gravity, 214 p. In: Problems of Space Biology, Vol. 74 (Nauka, Moscow, 1994) [in Russian].
5. Litovka I. G. Dosed hypoxia correction effect on the weightlessness osteopenia. Kosm. nauka tehnol., 8 (4), 81—85 (2002) [in Russian].
6. Litovka I. G., Berezovska O. P. The oxygen deprivation as the osteogenesis initiator under the hypokinesia. Fiziol. zhurn., 49 (2), 58—65 (2003) [in Ukrainian].
7. Oganov V. S. Hipokinesia - the factor of risk of osteoporosis. Osteoporoz i osteopatii, No. 1, 13—17 (1988) [in Russian].
8. Prabhakar N. R. Physiological and genomic consequences of intermittent hypohia. J. Appl. Physiol., 90 (5), 1986—1994 (2001).
9. Premkumar D. R. Intracellular pathways linking hypoxia to activation of c-fos and AP-1. Adv. Exp. Med. Biol., No. 475, 101 — 109 (2000).
10. Semenza G. HIF-1: mediator of physiological and pathophysiological responses to hipoxia. Cell, 88 (4), 1474—1480 (2000).

11. Wykoff C. C., Pugh C. W., Maxwell P. H., Harris A. L. Identification of novel hypoxia dependent target genes of the von Hippel-Lindau (VHL) tumor suppressor by mRNA differential expression profiling. Oncogene, No. 19, 6297—6305 (2000).