Two experimental setups for the investigation of cycle fatigue of structural materials under laboratory conditions are described. The first one simulates the orbital complex with appropriate test methods under space conditions. To simplify experimental means the methods provide only strain control mode with the specified predetermined total cycle amplitude (elastic and plastic) of strain. The second setup was designed for a comprehensive study of materials’ cyclic properties with obtaining of cyclic strain diagrams along with the data on the influence of available types of environment.