Effects of hypergravity stress on intensities of gaseous exchange, RNA and protein synthesis, thermoregulation, and survival of animals of different species

1Frol'kis, VV, 2Muradian, Kh.K, 2Timchenko, AN, 1Mozzhukhina, TG
1State Institution "Institute of Gerontology im.D.F.Chebotarova National Academy of Medical Sciences of Ukraine", Kyiv, Ukraine
2State Institution "D.F.Chebotarov Institute of Gerontology of the National Academy of Medical Sciences of Ukraine", Kyiv, Ukraine
Kosm. nauka tehnol. 1997, 3 ;(2):16-21
Publication Language: Russian
The effects of hypergravity (HG) stress on survival, gaseous exchange, thermoregulation, and synthesis of total RNA and protein were studied in adult male drosophilas, mice, and rats. Drosophilas had much higher HG tolerance (up to 20000 g) compared to mice and rats, for whom LD50 were 55—60g and 25g, correspondingly at a 10-minute exposure. In the groups of mice and rats, the gaseous exchange increased in the range of mild and sublethal HG, but it decreased in the lethal range of HG stress. In this range the body temperature, as well as RNA and protein synthesis in myocardium, frontal cortex, and hypothalamus also decreased; by contrast, synthesis processes increased in cerebrellum. In the post-stress period the gaseous exchange and body temperature recovered in about 1-2 hours.
Keywords: RNA and protein synthesis, space life sciences, space medicine
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